Exciting news from IndiCell, with a study on generation of induced pluripotent stem cells (iPSCs) and neural stem cells (NSCs) being published in Advanced Science, a respected interdisciplinary science journal.
Successful collaboration within IndiCell
Led by researchers from the Herland lab at KTH and the Falk lab at Lund University, this research presents a simplified and resource saving method for generating iPSCs. By employing microfluidic technology, the team substantially reduces resource requirements for cell reprogramming, making the process more efficient and sustainable by decreasing reagent usage by 100-fold and reduces the number of input cells by 9-fold, enhancing cost-effectiveness. The described IndiCell microfluidic method not only decrease resource usage but also showed enhanced commitment to the neural stem cell lineage, resulting in faster and better production of iPSC derived neural cell therapies. This novel method developed by IndiCell will pave the way for future automation of iPSC derived cell therapies in closed system without manual handling which will be instrumental for manufacturing large number of cell therapy doses and to reducing variability between batches.
“Microfluidic reprogramming holds promise as a key factor in making autologous cell therapies affordable on an industrial scale in the future. By minimizing the surface area to volume ratio, signaling molecules can accumulate, promoting cellular processes. This not only results in a more homogeneous cell population but also enhances cost-effectiveness by reducing reagent usage.” Says, Alice Hägg, an IndiCell PhD student that have been working in the team of this novel study.
